Moyo, EnosMoyo, PerseveranceMashe, TapfumaneiDzobo, MatthiasChitungo, ItaiDzinamarira, Tafadzwa2023-09-292023-01Moyo, E., Moyo, P., Mashe, T., Dzobo, M., Chitungo, I. & Dzinamarira, T. Implementation of Public Health Genomics in Africa: lessons from the COVID‐19 pandemic, challenges, and recommendations. Journal of Medical Virology 2023; 95: e28295. doi:10.1002/jmv.28295.0146-6615 (print)1096-9071 (online)10.1002/jmv.28295http://hdl.handle.net/2263/92598DATA AVAILABILITY STATEMENT : Data sharing not applicable to this article as no data sets were generated or analysed during the current study.Public Health Genomics (PHG) is a relatively new field. The wide application of genomic technologies played a pivotal role in elucidating the full genomic sequence of the SARS-CoV-2 virus. This breakthrough proved to be the starting point in the manufacture of diagnostic kits and the subsequent making of vaccines. Beyond the COVID-19 pandemic, many African countries can take advantage of the various investments in genomic technologies to introduce and intensify the use of genomics for public health gain. Public Health Genomics effectively monitors, prevents, and manages non-communicable and infectious diseases. However, there are several challenges to implementing PHG in Africa. In this perspective article, we discuss the utilization of PHG during the COVID-19 pandemic, the lessons learned from using PHG to manage and contain the COVID-19 pandemic, as well as potential challenges Africa may face when putting PHG into practice compared to challenges of other regions. We also discuss our recommendations for overcoming these challenges.en© 2022 Wiley Periodicals Inc. This is the pre-peer reviewed version of the following article : Implementation of Public Health Genomics in Africa: lessons from the COVID‐19 pandemic, challenges, and recommendations. Journal of Medical Virology 2023; 95: e28295. doi:10.1002/jmv.28295. The definite version is available at : http://wileyonlinelibrary.com/journal/jmv.AfricaBenefitsChallengesCOVID-19 pandemicCoronavirus disease 2019 (COVID-19)Public health genomics (PHG)RecommendationsSDG-03: Good health and well-beingPostprint Article