Tyhali, AkhonaForbes, Patricia B.C.2023-01-192023-01Tyhali, A. & Forbes, P.B.C. 2023, 'N–nitrosamines in surface and drinking waters : an African status report', TrAC Trends in Analytical Chemistry, vol. 158, art. 116873, pp. 1-12, doi : 10.1016/j.trac.2022.116873.0165-9936 (print)1879-3142 (online)10.1016/j.trac.2022.116873https://repository.up.ac.za/handle/2263/88885N-Nitrosamines are considered highly carcinogenic and genotoxic compounds, which are formed in water largely due to chloramination or chlorination disinfection in the presence of ammonia. N-nitrosodimethylamine has particularly attracted interest due to its high carcinogenicity. This review seeks to provide a synopsis of the present state of knowledge on the occurrence, toxicity, and analysis of N-nitrosamines in African surface and drinking water and highlights limitations and future directions. Solid phase extraction is preferred for nitrosamines in water, whilst analysis is mainly based on GC-MS or LC-MS. Extensive research into the distribution and potential impacts of N-nitrosamines in water has not yet been achieved on the African continent. There is a need for comprehensive research towards the development of sensitive but facile analytical methods for N-nitrosamines, and the monitoring thereof in African water matrices, particularly in drinking water, in order to better assess potential human health implications.en© 2022 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in TrAC Trends in Analytical Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in TrAC Trends in Analytical Chemistry, vol. 158, art. 116873, pp. 1-12, 2023. doi : 10.1016/j.trac.2022.116873.NitrosamineDisinfection byproducts (DBPs)N-nitrosodimethylamineWater qualityAfricaPostprint Article