Ankrah, Alfred O.Creemers-Schild, DinaDe Keizer, BartKlein, Hans C.Dierckx, Rudi A.J.O.Kwee, Thomas C.Span, Lambert F.R.De Jong, Pim A.Sathekge, Mike MachabaGlaudemans, Andor W.J.M.2022-02-162022-02-162021-01-17Ankrah, A.O.; Creemers-Schild, D.; de Keizer, B.; Klein, H.C.; Dierckx, R.A.J.O.; Kwee, T.C.; Span, L.F.R.; de Jong, P.A.; Sathekge, M.M.; Glaudemans, A.W.J.M. The Added Value of [18F]FDG PET/CT in the Management of Invasive Fungal Infections. Diagnostics 2021, 11, 137. https://DOI.org/10.3390/diagnostics11010137.2075-4418 (online)10.3390/ diagnostics11010137http://hdl.handle.net/2263/83969Anatomy-based imaging methods are the usual imaging methods used in assessing invasive fungal infections (IFIs). [18F]FDG PET/CT has also been used in the evaluation of IFIs. We assessed the added value of [18F]FDG PET/CT when added to the most frequently used anatomy-based studies in the evaluation of IFIs. The study was conducted in two University Medical Centers in the Netherlands. Reports of [18F]FDG PET/CT and anatomy-based imaging performed within two weeks of the [18F]FDG PET/CT scan were retrieved, and the presence and sites of IFI lesions were documented for each procedure. We included 155 [18F]FDG PET/CT scans performed in 73 patients. A total of 216 anatomy-based studies including 80 chest X-rays, 89 computed tomography studies, 14 magnetic resonance imaging studies, and 33 ultrasound imaging studies were studied. The anatomy-based studies were concordant with the [18F]FDG PET/CT for 94.4% of the scans performed. [18F]FDG PET/CT detected IFI lesions outside of the areas imaged by the anatomy-based studies in 48.6% of the scans. In 74% of the patients, [18F]FDG PET/CT added value in the management of the IFIs.en© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseUltrasoundChest X-rayMagnetic resonance imaging (MRI)[18F]FDG PET/CTPositron emission tomography/computed tomography (PET/CT)Invasive fungal infection (IFI)Article