Terblanche, Alta J.Lang, A.C.Gray, Claudia L.Goddard, E.Karabus, S.Kriel, M.Manjra, Ahmed I.Risenga, Samuel MalamuleleVan der Spuy, D.A.Levin, M.E.2015-03-032015-03-032015-01Terblanche, AJ, Lang, AC, Gray, CL, Goddard, E, Karabus, S, Kriel, M, Manjra, AI, Risenga, SM, Van der Spuy, DA & Levin, ME 2015, 'Non-IgE-mediated food allergies', South African Medical Journal, vol. 105, no. 1, pp. 66.0256-9574 (print)2078-5135 (online)10.7196/SAMJ.9104http://hdl.handle.net/2263/43840Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis and eosinophilic oesophagitis, and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome, allergic proctocolitis and enteropathy syndromes. Diagnosing mixed or non-IgE-mediated allergy is challenging. A clear cause-effect relationship between exposure to the suspected food and symptoms is not always possible, as symptoms develop over time and are more chronic in nature. Skin-prick tests and specific IgE to the allergen are usually negative. An elimination diet may be necessary to diagnose non-IgE-mediated type food allergy. The suspected allergen should be excluded from the diet for 2 - 6 weeks under dietetic guidance to assess for improvement of symptoms. After symptom improvement, a rechallenge is necessary to definitively prove causal relation.en© 2015 Health & Medical Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0).Food allergiesNon-imunoglobulin E (IgE)Non-IgE-mediated food allergyEosinophilic oesophagitis (EoE)Atopic dermatitis (AD)Food protein-induced enterocolitis syndrome (FPIES)Food protein-induced allergic proctocolitisEosinophilic gastroenteritis (EG)Article