Ahmed, Marwan AwadMuntingh, George L.Rheeder, Paul2017-09-122017-09-122017-08-27Ahmed, M.A., Muntingh, G.L. & Rheeder, P. 2017, 'Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM', International Journal of Endocrinology, vol. 2017, art. no. 2452853, pp. 1-6.1687-8337 (print)1687-8345 (online)10.1155/2017/2452853http://hdl.handle.net/2263/62241Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.en© 2017 Marwan A. Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License.Peripheral neuropathy (PN)Type 2 diabetes mellitus (T2DM)Vitamin B12 deficiencyHyperhomocysteinemiaRiskFolateMellitusPrevalenceHomocysteineRacial differencesCobalamin deficiencyArticle