Roza, Ana Luiza Oliveira CorreaSousa, Emanuel MendesLeite, Amanda AlmeidaAmaral-Silva, Gleyson KleberMorais, Thayna Melo de LimaWagner, Vivian PetersenSchuch, Lauren FrenzelVasconcelos, Ana Carolina UchoaDe Arruda, Jose Alcides AlmeidaMesquita, Ricardo AlvesFonseca, Felipe PaivaAbrahao, Aline CorreaAgostini, MichelleDe Andrade, Bruno Augusto BenevenutoDa Silveira, Ericka Janine DantasMartínez-Flores, ReneRondanelli, Benjamin MartínezAlberdi-Navarro, JavierRobinson, LiamMarin, ConstanzaJunior, Jose Narciso Rosa AssuncaoValiati, RenatoFregnani, Eduardo RodriguesSantos-Silva, Alan RogerLopes, Marcio AjudarteHunter, K.D. (Keith)Khurram, Syed AliSpeight, Paul M.Mosqueda-Taylor, AdalbertoVan Heerden, Willem Francois PetrusCarlos, RomanWright, John M.Romanach, Mario JoseVargas, Pablo Agustin2021-03-032021-05Roza, A.L.O.C., Sousa, E.M., Leite, A.A. et al. 2021, 'Central odontogenic fibroma: an international multicentric study of 62 cases', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 131, no. 5, pp. 549-557.2212-4403 (print)2212-4411 (online)10.1016/j.oooo.2020.08.022http://hdl.handle.net/2263/78926OBJECTIVE : The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). STUDY DESIGN : Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. RESULTS : There were 43 females and 19 males (average age 33.9 years; range 8–63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. CONCLUSIONS : To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.en© 2020 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 131, no. 5, pp. 549-557, 2021. doi : 10.1016/j.oooo.2020.08.022.Central odontogenic fibroma (COdF)Postprint Article