Le Roux-Pullen, LericaVan der Zwan, Henriette2015-05-112015-05-112014-11-14Le Roux-Pullen, L. & Van der Zwan, H., 2014, 'Canine multi-drug resistance-1 mutation prevalence: A South African perspective', Journal of the South African Veterinary Association / Tydskrif van die Suid-Afrikaanse Veterinêre Vereniging 85(1), Art. #1139, 3 pages. http://dx.DOI.org/ 10.4102/jsava.v85i1.11391019-9128 (print)2224-9435 (online)10.4102/jsava.v85i1.1139http://hdl.handle.net/2263/45093The multi-drug resistance (mdr-1) gene mutation is a phenomenon well known to current veterinary practitioners. The mutation causes a predisposition for, amongst other phenomena, macrocyclic lactone-induced neurotoxicosis in affected canines, a condition that can be fatal. Various herding dog breeds can be heterozygous or homozygous for the mutation, and prevalence differs only slightly in dog populations between geographical regions. This report provides prevalence data of the canine mdr-1 mutation in 306 South African dogs.en© 2014. The Authors. Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License.Multidrug-resistant (MDR)Gene mutationCanine mdr-1 mutationDogs -- Diseases -- South AfricaSouth AfricaArticle