Adam, SumaiyaLombaard, H.A.D.T. (Hennie)2017-03-092016-12Adam, S & Lombaard, H 2016, 'Autologous intrauterine transfusion in a case of anti-U', Transfusion, vol. 56, no. 12, pp. 3029-3032.0041-1132 (print)1537-2995 (online)10.1111/trf.13806http://hdl.handle.net/2263/59352BACKGROUND : Minor red blood cell antibodies are becoming a more common cause of hemolytic disease of the newborn. Anti-U are a rare alloantibody found almost exclusively in people of black descent. There is limited experience to guide the management of pregnancies complicated by anti-U. Furthermore, there is often no suitable cross-matched blood available for transfusion of a patient with anti-U. CASE REPORT : A 21-year-old P0G1 presented at 25 weeks' gestation with D– disease in pregnancy. She had a significant indirect antiglobulin test titer of 512. Anti-U were identified and no suitable cross-matched blood was available. Maternal blood was prepared for autologous intrauterine fetal transfusion. Two such transfusions were performed. RESULTS : A healthy fetus delivered at 32 weeks that did not require phototherapy or an exchange transfusion. CONCLUSION : Autologous transfusion of prepared maternal blood provides a safe option for intrauterine fetal therapy in pregnancies complicated by rare alloantibodies.en© 2016 AABB. This is the pre-peer reviewed version of the following article : Autologous intrauterine transfusion in a case of anti-U), Transfusion, vol. 56, no.12, pp. 3029-3032, 2016. doi : 10.1111/trf.13806. The definite version is available at : http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1537-2995.Red blood cell antibodiesAnti-UHemolytic diseaseRare alloantibodiesPostprint Article