Stark, Roderick T.Pye, Dominic R.Chen, WenyiNewton, Oliver J.Deadman, Benjamin J.Miller, Philip W.Panayides, Jenny-LeeRiley, Darren LyallHellgardt, KlausHii, King Kuok (Mimi)2023-10-162023-10-162022-10Stark, R.T., Pye, D.R., Chen, W. et al. 2022, 'Assessing a sustainable manufacturing route to lapatinib', Reaction Chemistry and Engineering, vol. 7, no. 11, pp. 2420-2426, doi : 10.1039/d2re00267a.2058-9883 (online)10.1039/d2re00267ahttp://hdl.handle.net/2263/92873A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.en© The Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anti-cancer drugLapatinibQuantitative metricsSDG-03: Good health and well-beingSouth Africa (SA)Article