Cameron, Colin McKenzieBotha, Wilna F.Smit, B.H.J.Bigalke, R.D.Cameron, Colin McKenzieGilchrist, Frances M.C.Morren, A.J.Verster, Anna J.M.Verwoerd, Daniel WynandWalker, Jane B.De Kock, V.E.2016-07-062016-07-0620161976Cameron, CM, Botha, WF & Smit, BHJ 1976, 'Antibody response to and immunity induced by Corynebacterium pyogenes vaccine’, The Onderstepoort Journal of Veterinary Research, vol. 43, no. 3, pp. 97-103.0330-2465http://hdl.handle.net/2263/53681The articles have been scanned in colour with a HP scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to final presentyation PDF-Format.A procedure is described for producing a high quality C. pyogenes vaccine. A satisfactory antibody response was obtained by administering 3 subcutaneous injections of vaccine at 10-day intervals, using doses of 2,0 ml for rabbits, 5,0 ml for sheep and 10,0 ml for cattle. The titres resulting from this procedure compared favourably with those obtained from following the more intensive schedule and higher doses of vaccine recommended by the British Veterinary Codex. The antibody response was at its best 1-2 months after immunization but dropped to a plateau 6 months after immunization. Mice were also successfully immunized against challenge with 1, 5 x 10⁸ organisms by the application of 3 doses of vaccine administered at 10-day intervals.en©1976 ARC-Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©2016 University of Pretoria. Department of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaArticle