Fouotsa, HuguesLannang, Alain MeliDzoyem, Jean PaulTatsimo, Simplice J.N.Neumann, BeateMbazoa, Celine DjamaRazakarivony, Andrianambinina AndriamarolahyNkengfack, Augustin EphremEloff, Jacobus NicolaasSewald, Norbert2016-08-302016-08-302015-05Fouotsa, H, Lannang, AM, Dzoyem, JP, Tatsimo, SJN, Neumann, B, Mbazoa, CD, Razakarivony, AA, Nkengfack, AE, Eloff, JN & Sewald, N 2015, 'Antibacterial and antioxidant xanthones and benzophenone from Garcinia smeathmannii', Planta Medica, vol. 81, no. 7, pp. 594-599.0036-8075 (print)1095-9203 (online)10.1055/s-0035-15458417005589445E-6204-2012http://hdl.handle.net/2263/56509A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7- dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2D NMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent Garcinia activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 μg/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals.en© 2015 Georg Thieme Verlag KG.Garcinia smeathmanniiGuttiferaeXanthoneBenzophenoneAntibacteriaAntioxidantsPostprint Article