Heartwater : Past, Present and Future. Workshop (1986 : Kruger National Park, South Africa)McHardy, N.MacKenzie, P.K.I.Bigalke, R.D.2014-12-052014-12-0520141987McHardy, N & MacKenzie, PKI 1987, 'Identification of drugs effective against Cowdria ruminantium using a mouse screening system’, Onderstepoort Journal of Veterinary Research, vol. 54, no. 3, pp. 481-484.0330-2465http://hdl.handle.net/2263/42810The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Heartwater is a tick-transmitted rickettsial infection of ruminants, caused by Cowdria ruminantium. The tetracyclines are the only compounds available for therapy of the disease. A screen, using mice infected with C. ruminantium, was developed and used to identify new compounds with potential for the control of heartwater. A series of di-4-methyl-thiosemicarbazones was shown to be highly active in the mouse model and their efficacy was confirmed in further trials in sheep infected with C. ruminantium. The mouse screen was shown to be simple to operate and reliably predictive of activity against heartwater. Ways in which the screen may be improved are suggested.en©ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©University of Pretoria. Dept. of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaHeartwater -- South AfricaArticle