Mzondo, BuntubonkeDlamini, NomusaMalan, F.P. (Frederick)Labuschagne, PhilipBovilla, Venugopal R.Madhunapantula, SubbaRao V.Maharaj, Vinesh J.2022-08-052021-06Mzondo, B., Dlamini, N., Malan, F.P. et al. 2021, 'Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra', Phytochemistry Letters, vol. 43, pp. 16-22, doi : 10.1016/j.phytol.2021.03.001.1874-3900 (print)1876-7486 (online)10.1016/j.phytol.2021.03.001https://repository.up.ac.za/handle/2263/86723Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549).en© 2021 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Phytochemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Phytochemistry Letters, vol. 43, pp. 16-22, 2021. doi : 10.1016/j.phytol.2021.03.001.Cleome gynandraDammarane triterpernoidsLung cancerBreast cancerColorectal cancer (CRC)Postprint Article