Outhoff, Kim2015-08-202015-08-202015Outhoff, K 2015, 'Switching antidepressants', South African Family Practice, vol. 57, no. 2, pp.32-34.2078-6190 (print)2078-6204 (online)http://hdl.handle.net/2263/49405Switching antidepressants because of lack of efficacy or unacceptable side-effects, while often required in general practice, may result in toxic drug-drug interactions, worsening depression or unpleasant discontinuation reactions. Switching strategies to minimise these risks include immediate switching, cross-tapering or incorporating a washout period. Immediate switching is generally possible when substituting a selective serotonin reuptake inhibitor or a serotonin and noradrenaline reuptake inhibitor for a drug from its own class. Cross-tapering over a period of weeks is preferred when switching between different antidepressant classes or from high-dose antidepressants. Dangerous interactions necessitate the observance of an adequate washout period when switching to and from monoamine oxidase inhibitors.en© 2015 The Author(s)Switching antidepressantsDiscontinuation reactionsImmediate switchingCross-taperingWashout periodArticle