Ballot, Daynia E.Ramdin, Tanusha D.Bandini, Rossella M.Nakwa, FirdoseVelaphi, SithembisoCoetzee, MelanthaMasemola, KhomotsoKali, Gugulabatembunamahlubi J.D.Horn, Alan R.Pillay, ShaktiVan Rensburg, JeannePepper, Michael Sean2022-10-182022-10-182021-12Ballot, D.E., Ramdin, T.D., Bandini, R.M. et al. Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy should not be discontinued in low- and middle-income countries. South African Medical Journal, vol. 111, no. 12, pp. 1168-1169, dec. 2021. doi:10.7196/SAMJ.2021.v111i12.16180.2078- 5135 (online)0256-9574 (print)10.7196/SAMJ.2021.v111i12.16180https://repository.up.ac.za/handle/2263/87763Perinatal asphyxia is a major cause of death and disability in children. Therapeutic hypothermia (TH) has become a standard of care for newborn infants who have sustained hypoxic ischaemic encephalopathy (HIE) due to perinatal asphyxia. There is compelling evidence to support this approach. A Cochrane systematic review of 11 prospective randomised controlled trials including 1 505 newborns showed that TH started within 6 hours of birth in infants with HIE significantly decreased mortality and neurodevelopmental disability in survivors.enThis open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.Therapeutic hypothermiaHypothermiaNeonatalLow- and middle-income countries (LMICs)Perinatal asphyxiaChildrenHypoxic ischaemic encephalopathy (HIE)Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy should not be discontinued in low- and middle-income countriesArticle