Van Aarde, M.N.Van Rooyen, J.M.Van Aswegen, G.Verwoerd, Daniel Wynand2013-08-272013-08-2720131996Van Aarde, MN, Van Rooyen, JM & Van Aswegen, G 1996, 'Screening of the venoms of two Parabuthus scorpion species on isolated cardiomyocytes’. Onderstepoort Journal of Veterinary Research, vol. 63, no. 2, pp. 127-130.0330-2465http://hdl.handle.net/2263/22070The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat X Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Crude, diluted venoms of Parabuthus transvaalicus and P. granulatus were tested on isolated cardiomyocytes. Ventricular myocytes were subjected to hypercontractility tests and whole-cell voltage clamp. Both venoms had a profound influence on the hypercontractility of cardiomyocytes, which was markedly decreased when they were pre-absorbed with commercial antiserum. Whole-cell clamp results showed an increase in the sodium current, and a retardation of the time course of inactivation, implicating the presence of an a toxin in both venoms.en© ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital).Veterinary medicineCardiomyocytesParabuthus granulatusParabuthus transvaalicusScorpionsVenomVeterinary medicine -- South AfricaArticle