Ismail, Nazir AhmedHoosen, Anwar AhmedSilberbauer, Eduard JohanVon Gottberg, Anne2011-11-212011-11-212011-11Silberbauer, EJ, Ismail, N, Von Gottberg, A & Hoosen AA 2011, 'Serotype and antimicrobial profile distribution of invasive pneumococcal isolates in the pre-vaccine introduction era in Pretoria, South Africa, 2005 through 2009', Diagnostic Microbiology and Infectious Diseases, vol. 71, no. 3, pp.309-311.[http://www.sciencedirect.com/science/article/pii/S0732889311003014]0732-8893 (print)1879-0070 (online)10.1016/j.diagmicrobio.2011.07.006 |http://hdl.handle.net/2263/17609A description of invasive Streptococcus pneumoniae isolates over a 5-year period from blood culture and cerebrospinal fluid culture follows, in Pretoria South Africa January 2005 through December 2009. Isolates were identified using standard microbiological techniques, serotyped, and a MIC determined for penicillin and cefotaxime. A total of 177 isolates were included in the analysis. Eighty percent of patients in the 18- to 45-year age group tested positive for HIV. In children <5 years of age, 66% (n = 49) of serotypes were those present in the heptavalent pneumococcal conjugate vaccine (PCV-7). Fifty-nine percent (n = 29) were from PCV-7 serotypes in the <1-year-old age group. An additional peak of invasive disease was also seen in the 18- to 45-year age group. Only 1 of 177 isolates had resistance to penicillin (MIC ≥2 μg/mL); none was resistant to cefotaxime. The introduction of the PCV-7 vaccine in South Africa will decrease invasive pneumococcal disease caused by vaccine serotypes.en© 2011 Elsevier. All rights reserved.South AfricaStreptococcus pneumoniaePneumococcusVaccinePneumococcus conjugate vaccineStreptococcus pneumoniae -- Effect of drugs on -- South AfricaAnti-infective agents -- South AfricaPostprint Article