Bosman, E.Esterhuizen, A.D.Rodrigues, Frederico AntonioBecker, Piet J.Hoffmann, W.A.2016-06-012015-11Bosman, E, Esterhuizen, AD, Rodrigues, FA, Becker, PJ & Hoffmann, WA 2015, 'Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males', Andrologia, vol. 47, no. 9, pp. 976-979.0067-270X (print)1945-5534 (online)10.1111/and.12366http://hdl.handle.net/2263/52823Previous reports indicated that hyperinsulinaemic men may exhibit a higher percentage of poorly compacted DNA in their spermatozoa and less success in an IVF programme (Andrologia, 45, 2003, 18; Andrologia, 2014, doi: 10.1111/ and.12227). The aim of this study was to investigate the effect of metformin (Glucophage ) and antioxidant treatment (StaminoGro ) on the semen parameters of hyperinsulinaemic men. Nineteen hyperinsulinaemic male patients were treated for 3 months with metformin alone (Group A), and fifteen patients used metformin in combination with the nutritional supplement (Group B). Combined data of the two groups (pre- and post-treatment) differ significantly regarding sperm morphology (P = 0.0003) and CMA3 (P < 0.0001) values. The improvement in sperm morphology after treatment was similar for the two respective groups (P < 0.05). The morphological normal sperm forms increased from the mean percentage of 3.9 to 5.5% and from 4.2 to 5.5% for Group A and B respectively. Where a combination of metformin and the supplement were used (Group B), the combination treatment proved to be superior in obtaining enhanced chromatin packaging quality although not statistically significant (P = 0.5929) when compared with the metformin (Group A) group. The chromatin packaging quality in Group B improved with 10% while the improvement in Group A was approximately 8.3%. Therefore, infertile hyperinsulinaemic men can benefit from metformin treatment and should be advised on the use of nutritional supplements with antioxidant properties.en© 2014 Blackwell Verlag GmbH. This is the pre-peer reviewed version of the following article : Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males in Andrologia, vol. 47, no. 9, pp. 976-979, 2015. doi :10.1111/and.12366. The definite version is available at : http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1439-0272.CMA3Male hyperinsulinaemiaMetforminMorphologyNutritional supplementHealth sciences articles SDG-03SDG-03: Good health and well-beingHealth sciences articles SDG-17SDG-17: Partnerships for the goalsPostprint Article