Miles, Christopher O.Wilkins, A.L.Erasmus, G.L.Kellerman, T. StephanusVerwoerd, Daniel Wynand2014-01-212014-01-2120131994Miles, CO, Wilkins, AL, Erasmus, GL & Kellerman, TS 1994, 'Photosensitivity in South Africa. VIII. Ovine metabolism of Tribulus terrestris saponins during experimentally induced geeldikkop’, Onderstepoort Journal of Veterinary Research, vol. 61, no. 4, pp. 351-359.0330-2465http://hdl.handle.net/2263/33042The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Geeldikkop was induced in a sheep by dosing it orally with a crude extract of the steroidal saponins from Tribulus terrestris. GC-MS analysis of the sheep's ruminal contents, bile, faeces and urine for free and conjugated sapogenins, revealed the general features of the metabolic pathway by which diosgenin and yamogenin glycosides were converted into the glucuronides of epismilagenin and episarsasapogenin, the major constituents of the biliary crystals that usually form during geeldikkop. Other steroidal saponins in the T. terrestris extract, including those derived from tigogenin, neotigogenin, gitogenin and neogitogenin, appear to be non-lithogenic. The implications of these findings are discussed.en© ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital).Veterinary medicinePlant poisoningVeterinary medicine -- South AfricaArticle