Karzis, JoanneDonkin, Edward FrancisPetzer, Inge-Marie2008-05-062008-05-062007-12Karzis, J, Donkin, EF & Petzer, I.M 2007, 'Withdrawal periods and tissue tolerance after intramammary antibiotic treatment of dairy goats with clinical mastitis', Onderstepoort Journal of Veterinary Research, vol. 74, no. 4, pp. 281-288. [http://www.journals.co.za/ej/ejour_opvet.html]0030-2465http://hdl.handle.net/2263/5122The aim of this study was to determine withdrawal periods (WP) and tissue irritation after administration of three intramammary antibiotics [Curaclox LC (Norbrook (ARK AH)], Spectrazol Milking Cow (Schering-Plough AH) and Rilexine 200 LC [Logos Agvet (Virbac)] in goats with clinical mastitis. Withdrawal periods in goats with clinical mastitis treated with Curaclox LC, were not significantly different from those recommended for use in cows (72 h) with (67 h) or without (48 h) the 24 h mandatory safety margin while Spectrazol caused a significantly longer withdrawal period (122 h) than that recommended for use in cattle with (60 h) and without (36 h) the 24h safety margin. The withdrawal period of clinical mastitis cases treated with Rilexine 200 LC was 48 h compared to the 96 h recommended for use in cows. A linear model of regression with factors influencing the WP in goats with clinical mastitis was as follows: WP = 30.21 + 4.692 (sampling time) + 22.11 (udder pathology) – 13.6 (floccules) – 0.00649 (milk yield).208829 bytesapplication/pdfenAgricultural Research Council, ARC-OVI and the University of PretoriaAntibiotic withdrawal periodsCalifornia Milk Cell TestClinical mastitisDairy goatsSomatic cell count (SCC)Tissue toleranceAntibiotics in veterinary medicineGoatsArticle