Robinson, LiamAbreu, Lucas GuimaraesFonseca, Felipe PaivaHunter, K.D. (Keith)Ambele, Melvin AnyasiVan Heerden, Willem Francois Petrus2024-08-072024-08-072024-03Robinson, L., Abreu, L.G., Fonseca, F.P., Hunter, K.D., Ambele, M.A. & Van Heerden, W.F.P. Ameloblastic carcinoma: A systematic review. Journal of Oral Pathology and Medicine 2024; 53 (3) : 174‐181. doi: 10.1111/jop.13517.0904-2512 (print)1600-0714 (online)10.1111/jop.13517.http://hdl.handle.net/2263/97477DATA AVAILABILITY STATEMENT : The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.SUPPLEMENTARY TABLE 1. Data from included studies.BACKGROUND : Ameloblastic carcinoma (AC) is the most common odontogenic malignancy, constituting approximately 30% of cases in this category. Literature is sparse on malignant odontogenic neoplasms, with a large proportion of current knowledge derived from case reports or small case series. METHODS : A systematic review of case series/case reports of AC was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Statement guidelines. Demographic and clinical information, including duration of the lesion, location, clinical presentation and radiologic features, were analysed. Additionally, the origin of the lesion (primary/secondary), Ki-67 proliferation index, treatment performed, metastasis, tumour recurrence and prognosis were collected for analysis. RESULTS : A total of 126 studies, including 285 individual cases of AC, were included in this review. Patients presented with a near-equal distribution of painless and painful swellings. ACs presented at a median age of 45 years, with a male-to-female ratio of 1:2. The mandible was most frequently involved, with rare cases extending to involve more than one region, including crossing the midline. Although most lesions presented with poorly-demarcated borders (52.6%), unilocular lesions with well-demarcated borders (47.4%) comprised a substantial number in the sample. The proliferation index was only reported in 27 cases, with a mean score of 42% and a wide range. The probability of tumour recurrence increased, and the survival probability decreased with prolonged follow-up duration. CONCLUSION : This study provides more comprehensive, up-to-date descriptive data on these rare odontogenic malignancies, aiding clinicians and Pathologists with the diagnosis and surgeons in their management of cases.en© 2024 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License.Ameloblastic carcinomaPreferred reporting items for systematic review and meta-analysis (PRISMA)Head and neck cancerOdontogenic neoplasmsRecurrence ratesSurvival probabilitySDG-03: Good health and well-beingArticle