Dziwornu, Godwin A.Mmonwa, Mmakwena M.Coertzen, DinaKrugmann, LiezlSalomane, NicolaasLeshabane, MetaThomas, Jean ArgyleDa Rocha, ShantéReader, JanetteMasike, KeabetsweNjoroge, MathewSevilleno, NicoleCoyle, RachaelBoonyalai, NonlawatMayville, EmilyLee, Marcus C.S.Fidock, David A.Coulson, Lauren B.Woodland, John G.Wicht, Kathryn J.Ghorpade, Sandeep R.Birkholtz, Lyn-MarieChibale, Kelly2025-11-182025-11-182025-08Dziwornu, G.A., Mmonwa, M.M., Coertzen, D. et al. 2025, 'Novel inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with low propensity for resistance: life cycle stage activity and in vivo efficacy in a humanized mouse malaria infection model', Journal of Medicinal Chemistry, vol. 68, no. 16, pp. 17736–17751, doi : 10.1021/acs.jmedchem.5c01417.0022-2623 (print)1520-4804 (online)10.1021/acs.jmedchem.5c01417http://hdl.handle.net/2263/105327SUPPORTING INFORMATION 1. Synthesis of intermediates; analytical spectra of compounds profiled in vivo; parasitology methods; PvPI4K and human kinase assays; in vitro ADME assays, and mouse pharmacokinetic and in vivo efficacy studies (PDF). SUPPORTING INFORMATION 2. In vitro data of all final compounds (mean IC50 values ± standard deviation (SD) or standard error (SE)) (CSV). SUPPORTING INFORMATION 3. Molecular formula strings (CSV).Please read abstract in the article.en© 2025 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 .AssaysInhibitionParasitesPhotovoltaicsRodent modelsAtaxia-telangiectasia-mutated (ATM)Artemisinin-based combination therapy (ACT)MalariaSeasonal malaria chemoprevention (SMC)Article