Bunn, Belinda KathleenHunter, K.D. (Keith)Khurram, Syed AliVan Heerden, Willem Francois Petrus2014-11-182014-11-182014-11Bunn, B, Hunter, K, Khurram, SA & Van Heerden, WFP 2014, 'Adenoid dysplasia of the oral mucosa', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 118, no. 5, pp. 586-592.2212-4411 (online)2212-4403 (print)10.1016/j.oooo.2014.08.009http://hdl.handle.net/2263/42650OBJECTIVE. To describe an unusual variant of oral epithelial dysplasia and to provide an appraisal of its immunohistochemical profile. STUDY DESIGN. An unusual form of epithelial dysplasia, which we have termed adenoid dysplasia, was evaluated for staining of cytokeratins AE1/AE3, vimentin, E-cadherin, and b-catenin. The immunohistochemical results were compared with those observed in moderate epithelial dysplasia, moderately differentiated squamous cell carcinoma, and acantholytic squamous cell carcinoma. RESULTS. The immunoprofile of adenoid dysplasia was similar to that of acantholytic squamous cell carcinoma. Cytokeratin positivity within the acantholytic dysplastic cells confirmed their epithelial nature, and upregulation of vimentin was suggestive of epithelial-mesenchymal transition. The most distinctive finding was a loss of E-cadherin expression within the discohesive cells, accompanied by increased cytosolic expression of b-catenin. CONCLUSIONS. This report presents the histomorphologic features of a unique form of oral epithelial dysplasia, termed adenoid dysplasia.en© 2014 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 118, no. 5. pp. 586-592, 2014. doi : 10.1016/j.oooo.2014.08.009.Oral epithelial dysplasiaAdenoid dysplasiaPostprint Article