Hinchcliff, Kenneth W.Morley, Paul S.Guthrie, Alan John2010-08-212010-08-212009-07Hinchcliff, KW, Morley, PS & Guthrie, AJ 2009, 'Efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses', Journal of the American Veterinary Medical Association, vol. 235, no. 1, pp. 76–82. [http://avmajournals.avma.org/loi/javma]0003-14887006535470J-6375-20130000-0001-7729-9918http://hdl.handle.net/2263/14724OBJECTIVE: To evaluate the efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage (EIPH) in Thoroughbred racehorses under typical racing conditions. DESIGN: Randomized, placebo-controlled, blinded, crossover field trial. ANIMALS: 167 Thoroughbred racehorses. PROCEDURES: Horses were allocated to race fields of 9 to 16 horses each and raced twice, 1 week apart, with each of the 2 races consisting of the same race field and distance. Each horse received furosemide (500 mg, IV) before one race and a placebo (saline solution) before the other, with the order of treatments randomly determined. Severity of EIPH was scored on a scale from 0 to 4 after each race by means of tracheobronchoscopy. Data were analyzed by means of various methods of multivariable logistic regression. RESULTS: Horses were substantially more likely to develop EIPH (severity score ≥ 1; odds ratio, 3.3 to 4.4) or moderate to severe EIPH (severity score ≥ 2; odds ratio, 6.9 to 11.0) following administration of saline solution than following administration of furosemide. In addition, 81 of the 120 (67.5%) horses that had EIPH after administration of saline solution had a reduction in EIPH severity score of at least 1 when treated with furosemide. CONCLUSIONS AND CLINICAL RELAVANCE: Results indicated that prerace administration of furosemide decreased the incidence and severity of EIPH in Thoroughbreds racing under typical conditions in South Africa.enAmerican Veterinary Medical AssociationHemorrhageRace horsesThoroughbred horseFurosemideLungs -- DiseasesHorses -- DiseasesArticle