Gathumbi, P.K.Mwangi, J.W.Njiro, S.M.Mugera, G.M.Verwoerd, Daniel Wynand2012-06-182012-06-1820122000Gathumbi, PK, Mwangi, JW, Njiro, SM & Mugera, GM 2000, 'Biochemical and haematological changes in rats administered an aqueous extract of Prunus africana stem-bark at various dosage levels’. Onderstepoort Journal of Veterinary Research, vol. 67, no. 2, pp. 123-128.0330-2465http://hdl.handle.net/2263/19202The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.An aqueous extract of Prunus africana (Hook. f.) Kalkm. (syn. Pygeum africanum) (Hook. f.) (Rosaceae) was administered daily at dosage rates of 10, 100 and 1000 mg/kg body mass to randomized groups of Sprague Dawley rats. The extract caused a moderate rise in plasma alanine aminotransferase and creatine kinase mainly at rates of 1000 mg/kg body mass, but it did not cause any significant variations in haematological parameters or in plasma levels of total proteins, albumin, aspartate aminotransferase, alkaline phosphatase and blood urea nitrogen at the dosage levels used. There were no overt clinical signs in any of the rats. It was concluded that the extract may contain components that are mildly toxic to the liver and heart of rats after repeated daily oral administrations of 1000 mg/kg body mass.© ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital).Veterinary medicineBiochemical dataHaematological dataPrunus africana extractVeterinary medicine -- South AfricaPrunus africanaVeterinary medicine -- ResearchRats as laboratory animalsArticle