Melong, RaduisMaffo, TimoleonKapche, Deccaux G.W.F.Ngadjui, Bonaventure T.2017-07-312017-07-312017-03Dzoyem J.P., Melong R., Tsamo A.T., Maffo T., Kapche D.G.W.F., Ngadjui B.T., McGaw L.J. & Eloff J.N. 2017, 'Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica', Revista Brasileira de Farmacognosia/Brazilian Journal of Pharmacognosy, vol. 27, pp. 251-253.0102-695X10.1016/j.bjp.2016.08.011http://hdl.handle.net/2263/61529Four compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25 g/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50values ranged from 40.42 to 86.56 g/ml, 31.87 to 86.57 g/ml and 21.59 to 67.27 g/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections.en© 2016 Sociedade Brasileira de Farmacognosia. This is an openaccess article under the CC BY-NC-ND license.AntimicrobialFree radical scavengingCytotoxicityEndophytic fungiEpicoccum nigrumArticle