Kellerman, T. StephanusMarasas, Walter F.O. (Walter Friedrich Otto)Thiel, P.G.Gelderblom, W.C.A.Cawood, M.Verwoerd, Daniel Wynand2014-09-012014-09-0120131990Kellerman, TS, Marasas, WFO, Thiel, PG, Gelderblom, WCA, Cawood, M & Coetzer, JAW 1990, 'Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B₁’, Onderstepoort Journal of Veterinary Research, vol. 57, no. 4, pp. 269-275.0330-2465http://hdl.handle.net/2263/41861The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Leukoencephalomalacia (LEM) was induced by the oral administration of fumonisin B₁ (FB₁) to 2 horses: a filly received 59,5mg/kg of a 50% preparation of FB₁ administered in 21 doses of 1,25-4mg/kg over 33 days; a colt, 44,3mg/kg of 95% pure FB₁ in 20 doses of 1-4 mg/kg in 29 days. Both animals developed nervous signs such as apathy, changes in temperament, inco-ordination, walking into objects, and one showed paralysis of the lips and tongue. Characteristic lesions of LEM were present in the brains. These trials proved conclusively that FB₁ can induce LEM in horses.en©South Africa. Dept. of Agricultural Technical Services. ©University of Pretoria. Dept. of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaArticle