Brauer, MariekeNagel, LizelleVan den Berg, Sylvia2025-02-262025-02-262024-12Brauer, M., Nagel, L., Van den Berg, S. 2024, 'Dr Spur's mystery case HSV : can it be a clue to an underlying inborn error of immunity?', Current Allergy & Clinical Immunology, vol. 37, no. 4, pp. 213-218, doi : 10.10520/ejc-caci-v37-n4-a11.1528-4050 (print)1473-6322 (online)10.10520/ejc-caci-v37-n4-a11http://hdl.handle.net/2263/101208HSV - can it be a clue to an underlying inborn error of immunity? I was recently contacted by a wife, concerned about her previously healthy 54-year-old husband, who suddenly complained of a severe headache. She noticed that he had difficulty speaking and seemed to be of balance. I arranged with a specialist physician at the nearest hospital for emergency admission. A diagnosis of herpes simplex virus (HSV) type-1 encephalitis was made. The patient made a full recovery after a full course of intravenous acyclovir.en© The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License.Herpes simplex virus (HSV)Genetic factorsInborn errors of immunitySDG-03: Good health and well-beingSDG-10: Reduced inequalitiesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article