Lilian, R.P.Mutasa, B.Railton, J.Mongwe, W.McIntyre, J.A.Struthers, H.E.Peters, Remco P.H.2016-10-112017-01Lilian, RR, Mutasa, B, Railton, J, Mongwe, W, McIntyre, JA, Struthers, HE & Peters, RPH 2016, 'A 10-year cohort analysis of routine paediatric ART data in a rural South African setting', Epidemiology and Infection, vol. 145, no. 1, pp. 170-180.0950-2688 (print)1469-4409 (online)10.1017/S0950268816001916http://hdl.handle.net/2263/57086South Africa’s paediatric antiretroviral therapy (ART) programme is managed using a monitoring and evaluation tool known as TIER.Net. This electronic system has several advantages over paper-based systems, allowing profiling of the paediatric ART programme over time. We analysed anonymized TIER.Net data for HIV-infected children aged <15 years who had initiated ART in a rural district of South Africa between 2005 and 2014. We performed Kaplan–Meier survival analysis to assess outcomes over time. Records of 5461 children were available for analysis; 3593 (66%) children were retained in care. Losses from the programme were higher in children initiated on treatment in more recent years (P < 0·0001) and in children aged ≤1 year at treatment initiation (P < 0·0001). For children aged <3 years, abacavir was associated with a significantly higher rate of loss from the programme compared to stavudine (hazard ratio 1·9, P < 0·001). Viral load was suppressed in 48–52% of the cohort, with no significant change over the years (P = 0·398). Analysis of TIER.Net data over time provides enhanced insights into the performance of the paediatric ART programme and highlights interventions to improve programme performance.en© Cambridge University Press 2016. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/).Analysis of dataHIV/AIDSPaediatricsPublic healthHuman immunodeficiency virus (HIV)Acquired immune deficiency syndrome (AIDS)Antiretroviral therapy (ART)Article