Kgomo, Mpho K.Elganar, Ali A.Jeske, ChristianNagel, Jackoo2016-06-032016-06-032016-05Kgomo, MK, Elnagar, AA, Jeske C & Nagel, J 2016, 'Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and cirrhosis of the liver : a case report and literature review', South African Medical Journal, vol. 106, no. 5, pp. 463-464.0256-9574 (print)2078-5135 (online)10.7196/SAMJ.2016.v106i5.9614http://hdl.handle.net/2263/52859Patients with cirrhosis of the liver usually present with a small, shrunken liver and a large spleen. The presence of an unusually huge liver should prompt the treating doctor to look for another cause, as this may be treatable and improve the patient’s outcome. In South Africa tuberculosis and lymphoma in the presence of HIV infection should be excluded. Sinus histiocytosis with massive lymphadenopathy and cirrhosis is a rare combination and has not been reported before in the literature. This case is intended to make clinicians aware of this rare combination of diseases.en© 2016 Health & Medical Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0).PatientsDoctorHIV infectionHuman immunodeficiency virus (HIV)Cirrhosis of the liverArticle