Holborn, Megan A. (Ashley)Mellet, JuanitaJoubert, FourieBallot, D.Pepper, Michael Sean2025-03-072025-03-072025-04Holborn, M.A., Mellet, J., Joubert, F. et al. 2025, 'A possible genetic predisposition to suspected hypoxic-ischaemic encephalopathy', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1871, no. 4, art. 167732, pp. 1-13, doi : 10.1016/j.bbadis.2025.167732.0925-4439 (print)1879-260X (online)10.1016/j.bbadis.2025.16773http://hdl.handle.net/2263/101392DATA AVAILABILITY : No data was used for the research described in the article.Within the last decade, several studies have explored whether there might be a genetic component in hypoxic-ischaemic encephalopathy (HIE) that influences susceptibility to or outcomes following hypoxic-ischaemic injury. This review provides a comprehensive overview of the findings to date from published studies investigating the genetics of HIE. It also highlights some of the challenges faced by researchers, as well as recommendations for future research.en© 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Hypoxic-ischaemic encephalopathy (HIE)Genetics researchGenomicsVariantsSDG-03: Good health and well-beingSDG-15: Life on landArticle