Joseph, DarrenTintinger, Gregory RonaldKer, James A.Pannell, N.2022-01-282022-01-282021Joseph, D., Tintinger, G.R., Ker, J.A. et al. 2021, 'Adverse effects of biologic anti-inflammatory agents on the respiratory system : a review', African Journal of Thoracic and Critical Care Medicine, vol. 27, no. 2, pp. 53-59.2617-019110.7196/AJTCCM.2021.v27i2.117http://hdl.handle.net/2263/83512The therapy of autoimmune rheumatological conditions has undergone significant changes with the introduction of biologic antiinflammatory agents including cytokine antagonists and agents that interfere with the function of T and B cells or those that inhibit intracellular enzymes such as Janus kinase (JAK). Although useful to control inflammation, these agents may be associated with drug-induced lung disease, which may be difficult to differentiate from pulmonary disorders caused by the underlying autoimmune diseases. This review aims to provide a description of lung disease, both infectious and non-infectious, that may be induced by the administration of biologic anti-inflammatory agents with emphasis on inhibitors of tumour necrosis factor, interleukin-1, interleukin-6 and JAK.enSouth African Medical Association NPCJanus kinase (JAK)Biologic anti-inflammatory therapySide-effectsAdverse reactionsLung diseaseRheumatological conditionsDrug-induced lung diseaseTumour necrosis factorInterleukin-1Interleukin-6Article