Peters, Remco P.H.2019-12-132019-12-132019/09/062019Sibandze, BB 2019, Genotypic and phenotypic diversity of Mycobacterium tuberculosis strains in patients with concomitant pulmonary and extra-pulmonary tuberculosis, MSc Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/72686>S2019http://hdl.handle.net/2263/72686Dissertation (MSc)--University of Pretoria, 2019.future, more robust or higher-resolution genomic typing tools, such as target Next Generation Sequencing (t-NGS) or metagenomic analysis are recommended to improve our understanding of the complexity of infections and for detection of both minority and major variants within extrapulmonary and pulmonary specimens for better estimation of the extent of M. tuberculosis genotypic and phenotypic heterogeneity.en© 2019 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.UCTDTuberculosisPublic HealthMetagenomic analysisGenomic typing toolsMolecular diagnosticsHealth RisksPulmonary specimensGenotypic heterogeneityPhenotypic heterogeneityHealth sciences theses SDG-03SDG-03: Good health and well-beingHealth sciences theses SDG-10SDG-10: Reduced inequalitiesHealth sciences theses SDG-17SDG-17: Partnerships for the goalsDissertation11176866