Nel, ChaneRobinson, LiamVan Heerden, Willem Francois Petrus2022-07-072022-07-072021-07Nel, C., Robinson, L. & van Heerden, W.F.P. Ghost cell odontogenic carcinoma arising in the background of a calcifying odontogenic cyst. Oral Radiology 37, 537–542 (2021). https://doi.org/10.1007/s11282-020-00492-5.0911-6028 (print)1613-9674 (online)10.1007/s11282-020-00492-5https://repository.up.ac.za/handle/2263/86056Ghost cell odontogenic carcinoma (GCOC) is a rare malignant neoplasm, representing 3% of all ghost cell lesions of the jaws. They can arise de novo or from a pre-existing calcifying odontogenic cyst (COC) or dentinogenic ghost cell tumour (DGCT). A systematic review of the literature reported only 12 cases of a GCOC arising from a pre-existing COC. This report highlights an additional case of a GCOC arising from a pre-existing COC after 3 years in an adolescent male. The patient initially presented with a painless swelling of the right mandibular corpus. Panoramic radiographic examination showed an expansive unilocular radiolucent lesion. After 3 years, the radiographic features appeared more aggressive with increased expansion and cortical perforation. A wide surgical resection was performed, whereby the lesion was diagnosed as a GCOC. Due to the rarity of these malignant neoplasms, limited information is available regarding their biological behaviour. One-year follow-up revealed no clinical signs of recurrence.en© Japanese Society for Oral and Maxillofacial Radiology and Springer Nature Singapore Pte Ltd. 2020. The original publication is available at : http://link.springer.com/journal/11282.Ghost cell odontogenic carcinoma (GCOC)Calcifying odontogenic cyst (COC)Dentinogenic ghost cell tumour (DGCT)Odontogenic cystsOdontogenic tumoursGhost cell lesions of the jawsMalignant transformationMaxillofacial radiologyPostprint Article