Ker, James A.2012-11-282012-11-282012-10Ker, J 2012, 'The treatment of cholesterol : safety and efficacy of statin therapy', SA Pharmaceutical Journal, vol. 79, no. 9, pp. 27-28.1015-1362http://hdl.handle.net/2263/20580Statins are the most widely prescribed class of drugs worldwide, and also the most powerful cholesterol-lowering drugs currently available. Statins inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density cholesterol receptors on the hepatocyte surface are upregulated, leading to increased clearance of cholesterol. Cholesterol levels are reduced, which leads to a significant reduction in cardiovascular events, of 25-45%.en© MedpharmCholesterolStatin therapyCholesterol -- TreatmentArticle