Makuru, Molikuoa HarrietMaruma, FransNgwenya, EdwardMponda, Kelvin2025-06-182025-06-182025-04Makuru, M.H., Maruma, F., Ngwenya, E. & Mponda, K., 2025, ‘Clinico-pathologic profile of skin cancers in oculocutaneous albinism at Universitas Academic Hospital’, Health SA Gesondheid 30(0), a2906. https://doi.org/10.4102/hsag.v30i0.2906.1025-9848 (print)2071-9736 (online)10.4102/hsag.v30i0.2906http://hdl.handle.net/2263/102869DATA AVAILABILITY : The data that support the findings of this study are available from the corresponding author, F.M. upon Treasonable request.BACKGROUND : Oculocutaneous albinism (OCA) is a genetic disorder found worldwide. Skin cancer is a significant risk for people with albinism, particularly in Africa, where it is a major cause of death. Many patients delay seeking medical care until their skin lesions are in advanced stages. AIM : The aim of this study was to describe the clinico-pathological profile of skin cancers in patients with albinism at their initial presentation to our dermatology outpatient department. SETTING : This study was conducted at the dermatology department of Universitas Academic Hospital, Bloemfontein, South Africa. METHODS : A retrospective descriptive study covering June 2009 to July 2019 was conducted. Only records of oculo-cutaneous albinism patients diagnosed with skin cancer during their initial visit were included. RESULTS : Eighty-six patients with albinism were recorded, 37% (n = 32) of whom had skin cancer at their first visit. Females (81%) were more affected than males (19%). The majority of skin cancers were squamous cell carcinomas (SCCs) (54%) and basal cell carcinomas (BCCs) (46%). No melanomas were found. Most SCCs were classified as aggressive (80.4%), compared to 30.8% of BCCs. CONCLUSION : Almost 40% of OCA patients presented with skin cancer at their initial visit, highlighting the need for strengthening primary healthcare systems’ efficiency in ensuring early referrals for OCA patients. CONTRIBUTION : Education, socioeconomic support and awareness campaigns are sine qua non actionable factors that could help encourage early medical evaluation for all OCA patients.en© 2025. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.Oculocutaneous albinism (OCA)Skin cancerSquamous cell carcinoma (SCC)Basal cell carcinoma (BCC)MelanomaArticle