Janse van Rensburg, EstrelitaEngelbrecht, SusanVan Heerden, Willem Francois PetrusRaubenheimer, E.J.Schoub, Barry D.2007-07-252007-07-251995-05Janse van Rensburg, E, Engelbrecht, S, Van Heerden, WFP, Raubenheimer, E & Schoub BD 1995, 'Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample', In Vivo, vol. 9, no. 3, pp. 199-202. [http://www.iiar-anticancer.org/invivo/invivo_index.htm]0258-851Xhttp://hdl.handle.net/2263/3136This article was co-written by Prof Janse van Rensburg before she joined the University of Pretoria.The purpose of this study was to determine the presence of Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma (OSCC) patients from a black African population. Formalin fixed paraffin embedded blocks of OSCC of two randomly selected groups were investigated. Group 1 consisting of 57 blocks containing OSCC with a fragment of normal appearing adjacent/overlying epithelium. Group 2 consisted of 48 blocks containing only OSCC tissue without any normal appearing epithelium. The control group consisted of 38 non-malignant, non-viral associated lesions. A standard polymerase chain reaction (PCR) was used to amplify the Bam HI W-fragment using a nested primer set. EBV DNA was demonstrated in 14/57 (25%) blocks from Group 1, in 13/48 (27%) blocks from Group 2 and in 16/38 (42%) blocks from the control group. No evidence for a direct role of EBV in the process of malignant transformation of intraoral epithelial cells was found in this study.8503 bytesapplication/pdfenInternational Institute of Anticancer Research The publisher prohibits open access to the full text of this article.Squamous cell carcinoma -- Blacks -- AfricaEpstein-Barr virus -- Research -- Blacks -- AfricaArticle