Spellberg, BradWald-Dickler, NoahHoltom, PaulMeyer-Sautter, PascalCamp, AustinDiaz Diaz, AlejandroBuhamad, RanyaMeza Vazquez, Ali SebastianAguirre-Garcia, Gloria MayelaStanton, MatthewButler-Wu, Susan M.Chiu, IsabelleErgenc, ZeynepBhoojhawon, GuruMurri, RitaMaraolo, Alberto EnricoCabanilla, GabrielaRiccardi, NiccolòTshisevhe, VhudzaniBehenna, CurtisWilliams, Karen S.Kufel, Wesley D.Wojciaczyk, NataliaPimentel, Bernardo VidalMuyidi,, AhmedCosta, Rodrigo P.L.Motta, FabrizioBortolussi-Courval, ÉmilieLee, Todd C.McDonald, Emily G.Ghanem, BassamNelson, Zachary2026-01-302026-01-302025-11Spellberg, B., Wald-Dickler, N., Holtom, P. et al. 2025, 'Reply to Datta, “Is static or cidal antibiotic falsifiable?”', Antimicrobial Agents and Chemotherapy, vol. 69, no. 11, pp. 1-3. https://doi.org/10.1128/aac.01361-25.0066-4804 (print)1098-6596 (online)10.1128/aac.01361-25http://hdl.handle.net/2263/107716We would like to thank Dr. Datta for his interest in our article. Dr. Datta wishes to defend the static vs. cidal antibiotic model against “absolutist framing.” He invokes “mono-parametric” assays like “MBC/MIC ratios or…reactive oxygen species generation” to suggest that in vitro static vs. cidal phenomenology may be phenotypically real.en© 2025 Spellberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International license.Static vs. cidal antibiotic modelAbsolutist framingMono-parametricIn vitroReplyArticle