Pienaar, J.G.Basson, P.A.Van der Merwe, J.L.de B.Jansen, B.C.2016-11-092016-11-0920161966Pienaar, JG, Basson, PA & Van Der Merwe, JLde B 1966, 'Studies on the pathology of heartwater Cowdria (Rickettsia) ruminantium, Cowdry, 1926 I. Neuropathological changes’, Onderstepoort Journal of Veterinary Research, vol. 33, no. 1, pp. 115-138.0330-2465http://hdl.handle.net/2263/57849The journals have been scanned in colour with a HP 5590 scanner; 600 dpi. Adobe Acrobat v.11 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.The most significant pathological changes in the central nervous system of 27 cases of heartwater are described. In addition to leucostasis and cell infiltration in the perivascular and subarachnoid spaces described previously, the following changes were noticed:- Swollen axis-cylinders, microcavitation and focal necrosis of the cerebellar cortex; degenerative and necrotic changes in the neuroglia accompanied by the formation of P.A.S. positive intracytoplasmic granules and globules; the accumulation of P.A.S. positive globules in the V.R. spaces; choriomeningeal oedema and fibrinous choriomeningitis; haemorrhages, oedema and vascular changes. Evidence is submitted in favour of the perivascular globules being proteinaceous and of glial origin.en© 1966 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © 2016 University of Pretoria. Dept. of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaArticle