Oberholzer, Hester MagdalenaVan der Schoor, CiskaBester, Megan Jean2016-02-102015-07Oberholzer, HM, Van der Schoor, C & Bester, MJ 2015, 'Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats', Environmental Toxicology and Pharmacology, vol. 40, no. 1, pp. 71-76.1382-6689 (print)1872-7077 (online)10.1016/j.etap.2015.05.011http://hdl.handle.net/2263/51319Sibutramine hydrochloride monohydrate is a weight loss agent indicated for the treatment of obesity. Although it has been banned from most markets, studies are still relevant as it is often a hidden ingredient in herbal and over the counter slimming products. Sibutramine induces liver fibrosis with steatosis in female Sprague-Dawley rats fed a high-energy diet without significant weight gain. In this study, using the same animal model, the effect of Sibutramine on lung morphology was investigated using histological evaluation of the terminal bronchiole and transmission electron microscopy evaluation of the respiratory tissue. From these results Sibutramine was found to induce lung fibrosis in Sprague-Dawley rats as increased collagen synthesis, mast cell accumulation and aggregates of Bronchus Associated Lymphoid Tissue (BALT) in the terminal bronchiole as well as increased collagen deposition in the respiratory tissue was seen.en© 2015 Elsevier B.V. All rights reserved. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Environmental Toxicology and Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Environmental Toxicology and Pharmacology, vol. 40, no.1, pp. 71-76, 2015. doi :10.1016/j.etap.2015.05.011.SibutramineFibrosisMast cellsiBALTCollagenBronchus Associated Lymphoid Tissue (BALT)Health sciences articles SDG-03SDG-03: Good health and well-beingHealth sciences articles SDG-12SDG-12: Responsible consumption and productionPostprint Article