Kruger, Taylor JuneKitshoff, Adriaan MynhardtSchoeman, Johan P.Hoepner, Sara NicoleneHanekom, Josef Derek2025-07-282025-07-282025Kruger, T.J., Kitshoff, A., Schoeman, J.P. et al. 2025, 'A persistent hymen resulting in an open cervix but closed pyometra and pyocolpos in a mixed-breed female domestic dog', Veterinary Record Case Reports, art. e70165, doi : 10.1002/vrc2.70165.2052-6121 (online)10.1002/vrc2.70165http://hdl.handle.net/2263/103617A rescued mixed-breed (Africanis type), entire, female dog, approximately 2 years old, with an unknown history, presented with a prominent perineal swelling between the anus and vulva. Ultrasound identified it as a fluid-filled structure, and an aspirate revealed an exudate consisting of degenerate neutrophils, bacterial cocci and rods. A vaginal exam showed a persistent hymen, while an abdominal ultrasound revealed distended, fluid-filled uterine loops consistent with a pyometra. Under general anaesthesia, an ovariohysterectomy was performed, and the persistent hymen was resected via an episiotomy to allow drainage of the purulent material. The surgery and recovery were without complications. This report describes an unusual presentation of a pyocolpos and ‘closed’ pyometra because of a persistent hymen.en© 2025 The Author(s). Veterinary Record Case Reports published by John Wiley & Sons Ltd on behalf of British Veterinary Association. This is an open access article under the terms of the Creative Commons Attribution License.Case reportPerineal swellingMixed-breedFemaleDomestic dogPyocolposClosed pyometraPersistent hymenOpen cervixArticle