Abbavaram, Babul Reddy A.Reddyvari, Hymavathi R.V.2014-05-292014-05-292013Abbavaram, BRA & Reddyvari, HRV 2013, 'Synthesis, characterization and antimicrobial activity of bifunctional sulfonamide-amide derivatives', Journal of the Korean Chemical Society, vol. 57, no. 6, pp. 731-737.1017-2548 (print)2234-8530 (online)10.5012/jkcs.2013.57.6.731http://hdl.handle.net/2263/39938A convenient synthesis of bifunctional sulfonamide-amide derivatives was reported. Amide coupling of 4-methyl benzoic acid 1 followed by reaction with chlorosulfonic acid produce ethyl-4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine- 1-carboxylate 4. The resulted compound on further treatment with various anilines produces the title sulfonamide-amide derivatives 5a−n. The configurations of these compounds were established by elemental analysis, IR, 1H NMR, mass spectra, and by their preparation from the corresponding 4-methyl benzoic acid 1 and chlorosulfonic acid. All these new compounds demonstrate significant in vitro antibacterial and antifungal activities against all bacterial and fungal strains.enKorean Chemical Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution LicenseSulfonamide-amide4-Methyl benzoic acidChlorosulfonicAntibacterial and antifungal activitiesArticle