Bell-Sakyi, LesleyZweygarth, ErichBlouin, Edmour F.Gould, Ernest A.Jongejan, Frans2007-09-262007-09-262007-09Bell-Sakyi, L, Zweygarth, E, Blouin, EF, Gould, EA & Jongejan, F 2007, ‘Tick-host-pathogen interactions in the post-genomic era’, Trends in Parasitology, vol. 23, no. 9, pp. 450-457 [http://www.sciencedirect.com/science/journal/14714922]1471-492210.1016/j.pt.2007.07.009http://hdl.handle.net/2263/3557Over 40 cell lines are currently available from 13 ixodid and one argasid tick species. The successful isolation and propagation of several economically important tick-borne pathogens in tick cell lines has created a useful model to study interactions between tick cells and these viral and bacterial disease agents. Tick cell lines have already proved to be a useful tool in helping to define the complex nature of the host–vector–pathogen relationship. With the availability of genomics tools, tick cell lines will become increasingly important as a complement to tick and tick-borne disease research in vivo once genetic transformation and gene silencing using RNA interference become routine.426513 bytesapplication/pdfenElsevierTick-borne diseasesTicksTick-borne diseases -- ResearchTicks as carriers of diseaseTicks -- ResearchHost-parasite relationshipsPostprint Article