Simmonds, W.M.Brand, MartinCoovadia, K.Lala, V.Naidoo, V.Seabi, N.Setshedi, M.Sonderup, M.Watermeyer, G.Fredericks, E.2025-11-032025-11-032025-09Simmonds, W.M., Brand, M., Coovadia, K. et al. 2025, 'SAGES dyspepsia guidance', South African Journal of Gastroenterology and Hepatology, vol. 2, no. 2, pp. 51-56. https://doi.org/10.36303/SAJGH.2999.3078-177910.36303/SAJGH.2999.http://hdl.handle.net/2263/105084Dyspepsia is a common condition characterised by upper abdominal symptoms, including epigastric pain, bloating, and nausea. This guidance document provides a framework for managing dyspepsia, emphasising initial clinical assessment, risk stratification, and tailored treatment approaches. Non-invasive testing for Helicobacter pylori (H. pylori) and empiric proton pump inhibitor (PPI) therapy are recommended for low-risk patients. High-risk patients, or those with persistent symptoms, require upper endoscopy to evaluate for underlying pathology. Lifestyle and dietary modifications, acid suppression therapy, and H. pylori eradication therapy are the key treatment components. The guidance also outlines algorithms for managing dyspepsia, promoting informed decision-making and improving patient outcomes. By implementing these, healthcare practitioners can enhance patient care, alleviate symptoms, and improve the quality of life and health outcomes for patients with dyspepsia.en© 2025 The Author(s). Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License (CC BY NC).DyspepsiaSymptomsPatientsQuality of life (QoL)Helicobacter pylori (H. pylori)Proton pump inhibitor (PPI)Article