Currie, Bernice MerciaNeyt-Galetti, Nicole C.Olivier, TanyaVan der Merwe, PetraDibokwane, Lerato ShirleyReinhardt, Anshe MichelleVan Wyk, Lorinda T.Panayides, Jenny-LeeRiley, Darren Lyall2025-07-032025-07-032025-03Currie, B.M., Neyt-Galetti, N.C., Olivier, T. et al. 2025, 'Synthesis of an 8-membered oxygen-containing benzo-fused heterocycle using flow technologies - an exercise in undertaking research with sustainability as a driver', RSC Sustainability, vol. 3, no. 3, pp. 1356-1365, doi : 10.1039/d4su00528g.2753-8125 (online)10.1039/d4su00528ghttp://hdl.handle.net/2263/103170DATA AVAILABILITY : The data supporting this article have been included as part of the Supplementary Information.Due to their natural abundance and biological properties, benzo-fused heterocycles are attractive targets in the field of drug discovery. Previously, a synthetic strategy for accessing 5-, 6-, 7- and 8-membered oxygen-containing benzo-fused heterocycles with the oxygen atom in the less commonly encountered 2-position was reported, however, the approach was hindered by long reaction times and a reliance on high boiling point solvents such as DMF. Targeting an 8-membered analogue as an exemplar, we highlighted that the adoption of basic green chemistry principles coupled with the use of flow chemistry techniques could be utilised (with limited development time) to improve day-to-day sustainability when performing synthetic research. In the case in hand, several key improvements were noted including (i) a higher overall yield (37% vs. 26%), (ii) a significantly reduced reaction time (110 min vs. 136 h) and (iii) the avoidance of the undesirable solvent DMF.en© 2025 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Benzo-fused heterocyclesDrug discoverySustainabilityFlow technologies,Green chemistryArticle