Kirschnick, Laura BorgesSilveira, Felipe MartinsSchuch, Lauren FrenzelVasconcelos, Ana Carolina UchoaGomes, Ana PaulaDos Santos, Jean NunesSantana, Dandara AndradeFonseca, Felipe PaivaMesquita, Ricardo AlvesDe Mendonça, Elismauro FranciscoSousa-Neto, Sebastiao SilverioPontes, Helder Antonio RebeloRobinson, LiamVan Heerden, Willem Francois PetrusCarlos-Bregni, RomanTager, Elena Maria Jose RomanDa Silva, Luan CesarZanella, Virgílio GonzalesRivero, Luis FernandoBittencourt, RaquelMartins, Marco Antonio TrevizaniLopes, Marcio AjudarteWagner, Vivian PetersenVargas, Pablo AgustinMartins, Manoela Domingues2024-04-182024-04-182023Kischnick, L.B., Silveira, F.M., Schuch, L.F. et al. 2023, 'Acinic cell carcinoma of the oral and maxillofacial region : an international multicenter study', Brazilian Oral Research, vol. 37, no. e050, pp. 1-11. https://DOI.org/10.1590/1807-3107bor-2023.vol37.0050.1517-749110.1590/1807-3107bor-2023.vol37.0050http://hdl.handle.net/2263/95630The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.en© This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.CarcinomaSalivary gland neoplasmsRetrospective studiesAcinic cell carcinoma (AciCC)Oral and maxillofacial regionSDG-03: Good health and well-beingArticle