Mulaudzi, Fhumulani MavisPhiri, Salaminah S.Peu, Mmapheko DoriccahMataboge, M.L.S. (Mamakwa L. Sanah)Ngunyulu, Roinah NkhensaniMogale, Ramadimetja Shirley2016-06-152016-06-152016-05-06Mulaudzi FM, Phiri SS, Peu DM, Mataboge MLS, Ngunyulu NR, Mogale RS. Challenges experienced by South Africa in attaining Millennium Development Goals 4, 5 and 6. Afr J Prm Health Care Fam Med. 2016;8(2), a947. http://dx. DOI.org/ 10.4102/phcfm.v8i2.947.2071-2928 (print)2071-2936 (online)10.4102/phcfm.v8i2.947http://hdl.handle.net/2263/53229BACKGROUND : Despite progress made by other countries worldwide in achieving Millennium Development Goals (MDGs) 4, 5 and 6, South Africa is experiencing a challenge in attaining positive outcomes for these goals. OBJECTIVE AND SETTING : To describe the challenges experienced by South Africa regarding the successful implementation of MDGs 4, 5 and 6. METHODS : An integrative literature review was used to identify and synthesise various streams of literature on the challenges experienced by South Africa in attaining MDGs 4, 5 and 6. RESULTS : The integrative review revealed the following themes: (1) interventions related to child mortality reduction, (2) implementation of maternal mortality reduction strategies, and (3) identified barriers to zero HIV and TB infections and management. CONCLUSION : It is recommended that poverty relief mechanisms be intensified to improve the socio-economic status of women. There is a need for sectoral planning towards maternal health, and training of healthcare workers should emphasise the reduction of maternal deaths. Programmes addressing the reduction of maternal and child mortality rates, HIV, STIs and TB need to be put in place.en© 2016. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.ImplementationMillennium Development Goals (MDGs)Human immunodeficiency virus (HIV)Tuberculosis (TB)South Africa (SA)Article