Motsoeneng, Boitumelo M.Manamela, NeliaKaldine, HaajiraKgagudi, PrudenceHermanus, TandileAyres, FrancesMakhado, ZaneleMoyo-Gwete, ThandekaVan der Mescht, Mieke AdriAbdullah, FareedBoswell, MichaelUeckermann, VeronicaRossouw, Theresa M.Madhi, Shabir A.Moore, Penny L.Richardson, Simone I.2024-06-132024-06-132023-08-03Motsoeneng, B.M., Manamela, N.P., Kaldine, H., Kgagudi, P., Hermanus, T., Ayres, F., Makhado, Z., Moyo-Gwete, T., Van der Mescht, M.A., Abdullah, F., Boswell, M.T., Ueckermann, V., Rossouw, T.M., Madhi, S.A., Moore, P.L. & Richardson, S.I.(2023) Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination. Frontiers in Immunology 14:1231276. DOI: 10.3389/fimmu.2023.1231276.1664-3224 (online)10.3389/fimmu.2023.1231276http://hdl.handle.net/2263/96467DATA AVAILABILITY STATEMENT : The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding authors.The kinetics of Fc-mediated functions following SARS-CoV-2 infection or vaccination in people living with HIV (PLWH) are not known. We compared SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in PLWH and people without HIV (PWOH) during acute infection (without prior vaccination) with either the D614G or Beta variants of SARS-CoV-2, or vaccination with ChAdOx1 nCoV-19. Antiretroviral treatment (ART)–naïve PLWH had significantly lower levels of IgG binding, neutralization, and antibody-dependent cellular phagocytosis (ADCP) compared with PLWH on ART. The magnitude of antibody-dependent cellular cytotoxicity (ADCC), complement deposition (ADCD), and cellular trogocytosis (ADCT) was differentially triggered by D614G and Beta. The kinetics of spike IgG-binding antibodies, ADCC, and ADCD were similar, irrespective of the infecting variant between PWOH and PLWH overall. However, compared with PWOH, PLWH infected with D614G had delayed neutralization and ADCP. Furthermore, Beta infection resulted in delayed ADCT, regardless of HIV status. Despite these delays, we observed improved coordination between binding and neutralizing responses and Fc functions in PLWH. In contrast to D614G infection, binding responses in PLWH following ChAdOx-1 nCoV-19 vaccination were delayed, while neutralization and ADCP had similar timing of onset, but lower magnitude,en© 2023 Motsoeneng, Manamela, Kaldine, Kgagudi, Hermanus, Ayres, Makhado, Moyo-Gwete, van der Mescht, Abdullah, Boswell, Ueckermann, Rossouw, Madhi, Moore and Richardson. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY).Humoral response kineticsPeople living with HIV (PLHIV)SARS-CoV-2 infectionChAdOx1 nCov-19 vaccinationNeutralizationFc Effector functionsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Antiretroviral therapy (ART)Antibody-dependent cellular phagocytosis (ADCP)Antibody-dependent complement deposition (ADCD)Antibody-dependent cellular trogocytosis (ADCT)SDG-03: Good health and well-beingArticle