Scheibe, AndrewSibeko, GoodmanShelly, ShaunRossouw, Theresa M.Zishiri, VincentVenter, Willem Daniel Francois2021-09-152021-09-152020-12-17Scheibe A, Sibeko G, Shelly S, Rossouw T, Zishiri V, Venter WDF. Southern African HIV Clinicians Society guidelines for harm reduction. S Afr J HIV Med. 2020;21(1), a1161. https:// DOI.org/ 10.4102/sajhivmed. v21i1.11611608-9693 (print)2078-6751 (online)10.4102/sajhivmed. v21i1.1161http://hdl.handle.net/2263/81853Additional inputs received from Lize Weich, Tanya Venter, Johannes Hugo, Urvisha Bhoora, Magriet Spies, Rafaela Rigoni, Cara O’Conner, Julia Samuelson, Viriginia Macdonald, Michelle Rodolph, Shona Dalal, Nurain Tisaker and Shaheema Allie. Regional harm reduction case studies developed by Kunal Naik (PILS, Mauritius) and Bernice Apondi (VOCAL, Kenya). Inputs from the guideline development workshop held in August 2019 are also included. Participants of the workshop included: Leora Casey, Andrew Gray, Harry Hausler, Signe Rotberga, Muhangwi Mulaudzi, Lauren Jankelowitz, Annette Verster, Busisiwe Msimanga-Radebe, Nontsikelelo Mpulo, Zukiswa Ngobo, Mpho Maraisane, Rogerio Phili, Kgalabi Ngako, Maria Sibanyoni, Yolanda Ndimande, Valencia Malaza, Johannes Hugo, Urvisha Bhoora and Cara O’Conner. We extend our thanks to the external reviewers, including Julie Bruneau, Annette Verster, Kunal Naik, Nkereuwem William Ebiti and Ali Feizzadeh.We support public-health-focused interventions, as opposed to recovery-focused interventions. We support the decriminalisation of drug use as much as we oppose the criminalisation of sex work, mandatory HIV disclosure and policing of sexual preferences.en© 2020. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.HIV/AIDSHarm ReductionPublic HealthClinical GuidelinesSubstance UseHealthcare AccessHIV PreventionSouthern AfricaVulnerable PopulationsHealth PolicyHealth sciences articles SDG-03SDG-03: Good health and well-beingHealth sciences articles SDG-10SDG-10: Reduced inequalitiesHealth sciences articles SDG-17SDG-17: Partnerships for the goalsArticle