Van Wyk, Lorinda T.Neyt, NicoleJugmohan, JaimeePanayides, Jenny-LeeRiley, Darren Lyall2024-01-182024-01-182024-01Van Wyk, L.T., Neyt, N.C., Jugmohan, J. et al. 2024, 'The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies', Reaction Chemistry & Engineering, vol. 9, no. 1, pp. 45-57, doi : 10.1039/d3re00443k.2058-9883 (online)10.1039/d3re00443khttp://hdl.handle.net/2263/94021Globally, major depressive disorders are a leading cause of disconsolateness affecting more than 300 million individuals. Bupropion is a unique dopamine-norepinephrine reuptake inhibitor (DNRI) commonly utilized in the treatment of depression, smoking cessation, ADHD and other addictions. Herein, we report our attempts to develop a greener, safer and more sustainable process for the preparation of bupropion hydrochloride employing flow chemistry. The use of obnoxious and corrosive liquid bromine was evaded through the employment of polymer-bound pyridinium tribromide and environmentally questionable solvents NMP and DMF were substituted with greener co-solvent systems with appreciable success. The final telescoped flow process afforded bupropion hydrochloride in a 69% overall yield, with improved process mass intensity, productivity and purity, as well as a reduction in reagents/solvents designated as red or amber in terms of H-codes.en© The Royal Society of Chemistry 2024. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dopamine-norepinephrine reuptake inhibitor (DNRI)Bupropion hydrochlorideFlow chemistryMajor depressive disorder (MDD)Article